{"id":17198,"date":"2023-06-22T09:05:09","date_gmt":"2023-06-22T08:05:09","guid":{"rendered":"https:\/\/actubusinessangels.com\/?p=17198"},"modified":"2023-06-22T09:05:09","modified_gmt":"2023-06-22T08:05:09","slug":"les-business-angels-des-grandes-ecoles-soutiennent-peptinov","status":"publish","type":"post","link":"https:\/\/www.franceangels.org\/en\/article\/les-business-angels-des-grandes-ecoles-soutiennent-peptinov\/","title":{"rendered":"Les Business Angels des Grandes Ecoles soutiennent Peptinov"},"content":{"rendered":"\n<p class=\"has-text-align-justify\">La soci\u00e9t\u00e9 de biotechnologie <strong><a rel=\"noreferrer noopener\" href=\"http:\/\/www.peptinov.fr\/#\/\" target=\"_blank\">Peptinov<\/a><\/strong> a lev\u00e9 4,67 millions d\u2019euros entre novembre 2022 et mars 2023 aupr\u00e8s de ses actionnaires historiques notamment le groupe de protection sociale IRCEM, FCB (holding du groupe Cegedim) et <strong><a rel=\"noreferrer noopener\" href=\"https:\/\/business-angels.info\/\" target=\"_blank\">BADGE<\/a><\/strong> (Les Business Angels des Grandes Ecoles).<\/p>\n\n\n\n<!--more-->\n\n\n\n<p class=\"has-text-align-justify\">Ces fonds serviront \u00e0 financer la pr\u00e9paration de son essai clinique de phase 2 visant \u00e0 \u00e9valuer l\u2019efficacit\u00e9 de son traitement innovant \u2013 l\u2019immunoth\u00e9rapie mod\u00e9ratrice de la prot\u00e9ine IL6 \u2013 dans l\u2019arthrose, et \u00e0 financer la pr\u00e9paration d\u2019essais cliniques dans de nouvelles indications.<\/p>\n\n\n\n<p class=\"has-text-align-justify\">Peptinov a mis au point une approche unique qui permet au patient de produire des anticorps dirig\u00e9s contre ses propres prot\u00e9ines afin d\u2019\u00e9viter les cons\u00e9quences n\u00e9fastes d\u2019un exc\u00e8s de leur production. Ainsi la surproduction continue de la prot\u00e9ine inflammatoire IL-6, la premi\u00e8re cible de Peptinov, est un acteur majeur dans l\u2019instauration d\u2019une inflammation chronique, l\u2019inflammation de bas grade, \u00e0 l\u2019origine de nombreuses maladies. Enjeu majeur de sant\u00e9 publique, l\u2019arthrose fait partie des nombreuses maladies dont la progression pourrait \u00eatre stopp\u00e9e par le traitement de Peptinov.<\/p>\n\n\n\n<p class=\"has-text-align-justify\">La strat\u00e9gie d\u2019immunoth\u00e9rapie active contre l&#8217;IL-6 d\u00e9velopp\u00e9e par Peptinov mobilise les propres anticorps du patient. Forte de son expertise en immunologie et en bio-informatique, l\u2019entreprise a identifi\u00e9 et brevet\u00e9 une s\u00e9quence peptidique sp\u00e9cifique de l\u2019IL-6, puis con\u00e7u un conjugu\u00e9 immunog\u00e8ne en la combinant \u00e0 une prot\u00e9ine porteuse. Une fois inject\u00e9 au patient, le conjugu\u00e9 est consid\u00e9r\u00e9 comme \u00e9tranger par le syst\u00e8me immunitaire qui d\u00e9clenche alors la production d\u2019anticorps qui vont neutraliser en partie l\u2019activit\u00e9 biologique de l\u2019IL-6, ce qui abaisse le niveau d\u2019inflammation et bloque la progression de l\u2019arthrose.<\/p>\n\n\n\n<p class=\"has-text-align-justify\">Contrairement aux m\u00e9dicaments actuellement sur le march\u00e9, qui se limitent au traitement symptomatique de l\u2019arthrose, l\u2019approche th\u00e9rapeutique d\u00e9velopp\u00e9e par Peptinov, en s\u2019attaquant \u00e0 l\u2019inflammation chronique de bas grade, cible l\u2019une des causes majeures de cette affection rhumatologique. Il s\u2019agirait du premier traitement de l\u2019arthrose par immunoth\u00e9rapie active.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Les Business Angels des Grandes Ecoles investissent Peptinov<\/p>\n","protected":false},"author":114,"featured_media":17204,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false},"categories":[162,85,60],"tags":[63,670,75,748],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.7.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Les Business Angels des Grandes Ecoles soutiennent Peptinov - France Angels<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.franceangels.org\/en\/article\/les-business-angels-des-grandes-ecoles-soutiennent-peptinov\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Les Business Angels des Grandes Ecoles soutiennent Peptinov - 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